The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Jeffrey M. Zacks
Project Title: IMPROVING EVERYDAY MEMORY IN HEALTHY AGING AND EARLY ALZHEIMER’S DISEASE
Date: August 20, 2024 at 12:29 pm
Request ID: S2406
Aim 1: Test whether and how attention to event segmentation improves elders memory for everyday activity at delays from minutes to weeks.
Aim 2: Test the hypothesis that effective event segmentation improves the resolution of elders posterior/medial memory representations.
Aim 3: Test whether the mechanisms and consequences of segmentation improvement are maintained or impaired by early symptomatic Alzheimer disease.
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Investigator: Tammie Benzinger
Project Title: The ADRC Consortium for Clarity in ADRD Research Through Imaging (CLARiTI)
Date: August 8, 2024 at 2:23 pm
Request ID: S2405
Aim 1: a. Aim 1. (Operational) Create a foundational shared resource: (i) Leverage the extensive ADRC program to conduct uniform amyloid, tau, FDG, and MRI scans together with plasma ADRD biomarkers in a large clinically heterogenous brain-donor-enrolled multi-ADRC cohort.
Aim 2: b. Aim 2. Deeply characterize disease burden for AD and ischemic small vessel disease (~V), the two most common diseases in the aging brain, and assess their effects on cognitive change.
Aim 3: c. Aim 3. Estimate likelihood of additional co-pathology and assess joint impact on cognitive change: While AD and V arguably have direct biomarkers of their underlying pathology, other common proteinopathies such as LBD and LATE unfortunately do not but may be estimated based on neurodegeneration p
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Investigator: Jonathan Kipnis
Project Title: Skin microbiome alterations in Alzheimer’s disease pathogenesis
Date: June 14, 2024 at 3:40 pm
Request ID: S2404
Aim 1: This study aims to explore the hypothesis that changes in the scalp microbiome of Alzheimer’s patients contribute to disease pathologenesis.
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Investigator: Sarah Walter
Project Title: Engagement of general audiences in a virtual dementia conference
Date: June 10, 2024 at 10:51 am
Request ID: S2403
Aim 1: Assess whether inclusion in a virtual scientific conference, supported by small group discussions, will increase commitment to research.
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Investigator: Scott L Letendre, MD
Project Title: CHARTER Plus: A resource for cutting-edge research on neurological function and mental health in people with HIV and substance use disorders across the lifespan.
Date: April 10, 2024 at 10:40 am
Request ID: S2402
Aim 1: We are assessing the neurologic complications of HIV infection in people living with HIV. In addition, for comparative evaluation, we must enroll 10 HIV negative participants with a family history of dementia who are cognitively normal or with minor cognitive impairment and age >50 yrs.
Aim 2: Provide accurate and timely processing of research requests and distribution of requested data and biospecimens.
Aim 3: Provide a resource of scientific expertise to requestors regarding the cohort, its data and biospecimens, and analysis and interpretation of its data.
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Investigator: Dmitriy Yablonskiy
Project Title: Deep-Learning-Augmented Quantitative Gradient Recalled Echo (DLA-qGRE) MRI for in vivo Clinical Evaluation of Brain Microstructural Neurodegeneration
Date: February 10, 2024 at 3:17 pm
Request ID: S2401
Aim 1: To develop DLA-qGRE data processing pipeline, compatible with MRI protocols of commercially available GRE sequences, for fast and reliable detection of microstructural pre-atrophic neurodegeneration in patients with asymptomatic and early AD.
Aim 2: To optimize k-space sampling strategy for developing qGRE imaging protocol with 3D isotropic 1x1x1 mm3 resolution with MRI acquisition time of about 5 minutes.
Aim 3: To demonstrate that the DLA-qGRE protocols developed in Aims 1 and 2 will yield reliable depiction of microstructural neurodegeneration in preclinical and early symptomatic AD as assessed by clinical neuroradiologists as compared to NLLS-qGRE images.
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Investigator: Andrei Vlassenko
Project Title: Brain Metabolism during task-evoked and spontaneous activity in aging and Alzheimer’s disease
Date: October 30, 2023 at 8:32 am
Request ID: S2312
Aim 1: Determine metabolic correlates of BOLD deactivations during task performance.
Aim 2: Determine whether task-evoked changes in brain metabolism differ among young adults, healthy older adults, and older adults with AD.
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Investigator: Mary Politi
Project Title: Implementation and Pilot Testing Visual Informed Consent Documents
Date: October 27, 2023 at 9:25 am
Request ID: S2311
Aim 1: Implement and test implementation of a visual consent template and process in 1 non-cancer trial
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Investigator: Aisling Chaney
Project Title: Investigating whole-body innate immune activation in Alzheimer’s disease using PET imaging and immune profiling
Date: October 18, 2023 at 3:08 pm
Request ID: S2310
Aim 1: Investigate whole-body immune signatures associated with AD severity using TSPO-PET and blood-based immune profiling
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Investigator: Sarah Hartz
Project Title: Disentangling the relationship between alcohol consumption and biomarkers for Alzheimer disease and related dementias
Date: September 5, 2023 at 10:56 am
Request ID: S2309
Aim 1: Determine the current and longitudinal patterns of alcohol use among cognitively normal older adult participants in MAP, a longitudinal study of aging, and evaluate associations between alcohol use patterns and clinical onset of dementia.
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