The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Steve Petersen
Project Title: Cascading Failure in Networks
Date: [153]
Request ID: D1727
Aim 1: to see how networks change in dementia
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Investigator: Prof. Christos Davatzikos
Project Title: iSTAGING (Imaging-based coordinate SysTem for AGing and NeurodeGenerative diseases)
Date: [153]
Request ID: D1726
Aim 1: Our goal is to leverage current machine learning methods to measure patterns of brain atrophy, small vessel disease and functional connectivity; to distill imaging data down to a few dozen of informative dimensions, indices that quantify and distinguish resilient and advanced brain aging
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Investigator: Bruno A. Benitez
Project Title: Role of rare functional variants in genes of the autophagy/lysosome pathway in Alzheimer�s disease
Date: [153]
Request ID: D1725
Aim 1: We will identify ALP genes enriched with rare functional variants in AD
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Investigator: Dr. Chengjie Xiong
Project Title: A Comparison of longitudinal inferences of PET amyloid imaging and MRI volumetric markers with and without including individuals with only baseline data
Date: [153]
Request ID: D1724
Aim 1: To understand the amount of missing data on imaging modalities of WU ADRC databases
Aim 2: To investigate whether and how subjects with only baseline imaging data contribute to longitudinal inferences on imaging modalities, more specifically, how baseline data affect the estimates to the longitudinal rates of change in linear mixed models.
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Investigator: Hamied Haroon
Project Title: Quantima � Diagnostics Imaging Biomarkers
Date: [153]
Request ID: D1723
Aim 1: Generate diffusion atlas for healthy controls and participants diagnosed with Alzheimer’s disease
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Investigator: Gagan Wig
Project Title: The impact of socioeconomic status on brain aging across the adult lifespan
Date: [153]
Request ID: D1722
Aim 1: To examine whether socioeconomic status relates to age-associated changes in brain anatomy and resting-state network organization across the adult life-span, using longitudinal measures of brain anatomy and network organization.
Aim 2: To determine whether measures of brain integrity (white matter FA), pathology (cortical amyloid, white-matter hyperintensities, CSF AD biomarkers [t-tau, p-tau, Aβ42]), and APOE status moderates any of the SES-brain effects.
Aim 3: To investigate whether a change of status from cognitively normal (e.g., CDR=0) to demented (e.g., CDR>0) will be predicted by SES-related differences in the brain.
Aim 4: To investigate how the relationship between SES and age-related changes in cognition may be mediated or modified by changes in the various measures of brain anatomy and function.
Investigator: Christa Dang
Project Title: Meta-analysis of the clinical utility of robust vs conventional norms for neuropsychological tests
Date: [153]
Request ID: D1721
Aim 1: Comparing the clinical utility of robust vs conventional norms for neuropsychological tests (meta-analysis)
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Investigator: Dr Donna Roberts
Project Title: A Retrospective Analysis of the Med Ops MR Brain Scans of ISS Astronauts in order to Characterize Structural Brain Changes Following Long-term Spaceflight
Date: [153]
Request ID: D1720
Aim 1: Is there upward shift of the brain structures during spaceflight?
Aim 2: what is the accurate etiology of venous congestion?
Aim 3: Studying space-related syndromes such as visual impairment intracranial pressure (VIIP)?
Aim 4: syndromes: Intracranial hyperpressure, loss of vision acuity
Investigator: Dr. Mary C. Tierney
Project Title: Sex Differences in Visuospatial, Verbal Memory, and Frontal Executive Abilities in Parkinson’s Disease: A Meta-Analysis
Date: [153]
Request ID: D1719
Aim 1: To examine sex differences in Parkinson’s disease patients (PD), relative to controls, within the three main cognitive domains affected in PD: frontal executive, visuoaptial, and verbal memory.
Aim 2: To examine whether sex differences in PD cognitive decline are moderated by age of PD onset, or disease duration or severity
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Investigator: Ben Palanca
Project Title: Frequency of Eye Blinks and Sleep Spindles as A Marker of Postoperative Delirium Vulnerability
Date: [153]
Request ID: D1718
Aim 1: Evaluate the relationship of sleep spindle occurrence and the development of postoperative delirium
Aim 2: Assess the relationship of eye blink rate and the development of postoperative delirium
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