The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Jeffrey M Zacks
Project Title: Improving everyday memory in healthy aging and early AD
Date: February 11, 2021
Request ID: S2102
Aim 1: Test whether and how attention to event segmentation improves elders� memory for everyday activity at delays from minutes to weeks.
Aim 2: Test the hypothesis that effective event segmentation improves the resolution of elders� posterior/medial memory representations.
Aim 3: Test whether the mechanisms and consequences of segmentation improvement are maintained or impaired by early symptomatic Alzheimer�s disease.
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Investigator: Catherine Roe and Ganesh Babulal
Project Title: Naturalistic driving as a functional neurobehavioral marker of preclinical and symptomatic Alzheimer disease (AD)
Date: January 5, 2021
Request ID: S2101
Aim 1: Use established cerebrospinal fluid (CSF) and imaging biomarkers to define preclinical AD and test the ability of the DRIVES to distinguish persons with and without preclinical AD among cognitively normal older adults, and assess the ability of the system to predict the future onset of dementia.
Aim 2: Test the ability of the DRIVES data to distinguish cognitively normal persons from those with dementia cross-sectionally, and to examine driving behavior over time for both groups.
Aim 3: Determine whether the DRIVES data, combined with cognitive, health, and functional data from older adults, can improve prediction of incident cognitive impairment and dementia.
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Investigator: Sarah Hartz (MPI Jessica Mozersky)
Project Title: WeSHARE (WashU Study of Having AD dementia Research results Explained)
Date: December 9, 2020
Request ID: S2004
Aim 1: Determine impact of returning research results to participants
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Investigator: Kate McClannahan
Project Title: Assessing hearing difficulties in adults with dementia
Date: August 10, 2020
Request ID: S2003
Aim 1: Determine the relationship between objective measures of hearing and self-reported hearing handicap in adults with dementia
Aim 2: Quantify and compare measures of hearing handicap between individuals with dementia and their primary caregiver/communication partners
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Investigator: Taylor Levine
Project Title: Comparison of self- and informant-reported change in memory, attention, and spatial navigation in predicting preclinical Alzheimer disease
Date: July 10, 2020
Request ID: S2002
Aim 1: Compare the diagnostic accuracy of self- and informant- reported memory, attentional control, and spatial navigation in detecting preclinical AD
Aim 2: Examine the ability of questionnaires to predict preclinical AD when controlling for personality traits or current affective state
Aim 3: Compare the diagnostic accuracy of domain-specific questionnaires and the AD8 in detecting preclinical AD
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Investigator: Dean Foster Wong
Project Title: Comparison of Two Next Generation Tau Radiopharmaceuticals in Alzheimer’s Disease
Date: April 13, 2020
Request ID: S2001
Aim 1: Aim 1 To directly compare kinetics of 2nd generation Tau radioligand [F18]RO948 & [F18]MK6240 radioligands in the same older cognitively-normal control (OC) subjects and in clinically diagnosed Alzheimer�s Disease (AD) patients.
Aim 2: Aim 2 To examine whether these 2nd generation radioligands are free of off-target binding in the basal ganglia, thalamus & choroid plexus.
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Investigator: Cyrus A. Raji, MD, PhD
Project Title: Neuroinflammatory and Alzheimer’s Disease Imaging Biomarkers in Obesity
Date: December 11, 2019
Request ID: S1904
Aim 1: Aim 1: To determine the presence of neurodegeneration in MAOO compared to MNOO and control (normal BMI < 25) groups amongst cognitively normal participants in the Knight ADRC. We will define minimum criteria for MAOO of BMI 25 and HbA1c of 5.7, MNOO with BMI 25 and HbA1c < 5.7%
Aim 2: Aim 2: To determine differences between MAOO and MNOO in MR imaging and PET biomarkers of neuroinflammation. Characterizing neuroinflammation on MR imaging will be done using DBSI.
Aim 3: Aim 3: Comparison in MAOO versus MNOO in cognitively normal controls on imaging biomarkers of AD pathology with amyloid and tau PET.
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Investigator: Ganesh Babulal
Project Title: Dynamic models of successful aging and perceptions of AD risk among African Americans and Caucasians
Date: October 1, 2019
Request ID: S1903
Aim 1: Use Group Model Building to examine definitions of successful aging among African American and Caucasian older adults
Aim 2: Assess perceptions of AD risk on racial groups using system dynamics
Aim 3: Investigate how well being and quality of life of older adults in St Louis are impacted by perceptions of AD risk
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Investigator: Michael Weiner
Project Title: BHR Validation of Online Methods to Predict & Monitor Cognitive Decline
Date: March 26, 2019
Request ID: S1902
Aim 1: Use IRT to develop an electonic version of the CDR based on historical ISP data
Aim 2: Refine and pilot test online version of CDR and Financial Capacity Inventory
Aim 3: Validate both eCDR and eFCI in clinical cohort combining in-person CAs and online collection
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Investigator: Musiek; Holtzman; Ju
Project Title: Sleep and Circadian Rhythms in Alzheimer Disease: Potential bi-directional relationship with tau
Date: March 7, 2019
Request ID: S1901
Aim 1: Investigate the bi-directional relationships between sleep, circadian fragmentation and AD pathogenesis in humans
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