The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Mike Weiner (Awarded NIH Grant)
Project Title: Alzheimer’s Disease Neuroimaging Initiative 2 (ADNI2)
Date: December 21, 2021 at 5:29 pm
Request ID: S1011
Aim 1: Determine and define biomarkers which best predit future cognitive decline.
Aim 2: Determine biomarkers that can serve as outcome measures to quantify the rate of disease progression.
Aim 3: Define biomarker measures that can be used to develop the most effective clinical trial scenarios.
Aim 4: Validate diagnoses and imaging/biomarker measures through neuropath exam of ADNI participants.
Investigator: Hogue, Charles W.
Project Title: Relation between cognitive state before and after CABG surgery
Date: December 21, 2021 at 5:29 pm
Request ID: S0014
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Investigator: John Morris, MD
Project Title: Alzheimer’s Disease Neuroimaging Initiative-Grand Opportunity
Date: December 21, 2021 at 5:29 pm
Request ID: S1001
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Investigator: Meuser, Thomas M.
Project Title: Anticipatory Grief in Caregivers of Individuals with Alzheimer’s Disease
Date: December 21, 2021 at 5:29 pm
Request ID: S0011
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Investigator: Mark E. Wheeler
Project Title: Neural mechanisms of perceptual memory decisions in mild cognitive impairment
Date: December 21, 2021 at 5:29 pm
Request ID: S1012
Aim 1: Test whether parietal integrity affects performance in perceptual choice and recall tasks
Aim 2: Identify neural signals related to the integration of evidence over time.
Aim 3: Determine whether neural integration signals are affected in early stages of dementia
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Investigator: David M. Holtzman
Project Title: Sleep and amyloid-beta
Date: December 21, 2021 at 5:29 pm
Request ID: S1007
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Investigator: B. Joy Snider
Project Title: Protocol H8A-MC-LZAT Plasma Amyloid Beta Species after a Single Solanezumab Infusion in Nondemented
Date: December 21, 2021 at 5:29 pm
Request ID: S1005
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Investigator: Morris/Benzinger
Project Title: Quantitative PET Imaging without Arterial Blood Sampling
Date: December 21, 2021 at 5:29 pm
Request ID: S1013
Aim 1: To investigate the feasibility of image-based arterial input function (AIF) estimation.
Aim 2: To investigate the feasibility of quantification of amyloid-beta deposition using the estimated AIF
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Investigator: Morris/Benzinger
Project Title: Amyloid-beta Deposition in Aging: Quantitative Comparison of Two Amyloid Imaging Agents
Date: December 21, 2021 at 5:29 pm
Request ID: S1014
Aim 1: To add beta-amyloid plaque imaging with PET using AV-45 to the longitudinal assessments to KARI.
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Investigator: Binder/McDaniel
Project Title: Combining exercise and cognitive training to improve everyday function
Date: December 21, 2021 at 5:29 pm
Request ID: S1002
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