The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Investigator: Zongtao Tom Lin
Project Title: Transforming Post-translational Arginylation into Targeted Tau Degradation Against Alzheimer’s Disease
Date: September 21, 2023
Request ID: T2312
Aim 1: Identify arginylation substrates in AD brains using activity-based arginylome profiling (ABAP).
Aim 2: Establish targeted tau degradation via ATE1 recruitment using FKBP-Halo system.
Aim 3: Develop ArgTACs for targeted tau degradation.
Investigator: Rawan Tarawneh/Carlos Cruchaga
Project Title: Endothelial Markers in AD
Date: September 17, 2023
Request ID: T2311
Aim 1: Examine diagnostic and prognostic value of endothelial injury markers across different stages of AD
Aim 2: Evaluate relationship of endothelial injury to fluid and imaging markers of AD pathology and neurodegeneration
Aim 3: Characterize the contribution of endothelial injury to cognitive decline in preclinical and early symptomatic AD
Investigator: gregory wu
Project Title: MOG antibodies in neurodegenerative diseases
Date: July 19, 2023
Request ID: T2310
Aim 1: Determine the prevalence and titer of circulating MOG antibodies in patients with AD
Investigator: Carlos Cruchaga
Project Title: Large scale gene discovery for neurological traits
Date: July 10, 2023
Request ID: T2309
Aim 1: To generate WES for all the Knight-ADRC samples
Aim 2: To identify variants and genes associated with AD and ADRD
Aim 3: To determine the genetic overlap between AD, PD and other neurological traits
Investigator: Rion Pendergrass
Project Title: Identify novel biomarkers for Alzheimer’s from stratified Neurodegenerative disease data.
Date: July 6, 2023
Aim 1: Look closely at the data from AD cases and controls , cases include other neurodegenerative diseases.
Investigator: David Holtzman
Project Title: Evaluating the ability of gut microbiota to promote neuroinflammation and tau pathology
Date: June 8, 2023
Request ID: T2308
Aim 1: Determine how the human AD microbiome impacts tau pathology, neuroinflammation, and neurodegeneration in a germ-free model of tau-mediated neurodegeneration
Project Title: Biomarkers and Rates of Progression in Dementia (Bio-RaPID)
Date: June 2, 2023
Request ID: T2307
Aim 1: Define the “cellular contributors” to RPD, addressing the key question of what makes patients vulnerable to rapidly progressive dementia
Investigator: Qing Wang
Project Title: Association of CSF sTREM2 and plasma GFAP with an MRI measure of neuroinflammation
Date: April 19, 2023
Request ID: T2306
Aim 1: Compare DBSI neuroinflammation index to in vivo CSF and plasma inflammation biomarkers (sTREM2 and GFAP) in the Knight ADRC cohorts
Investigator: Andrew Kraft / Evan Macosko
Project Title: Cellular mechanics of white matter disease
Date: April 15, 2023
Request ID: T2304
Aim 1: Determine spatial heterogeneity in healthy WM cell type composition and gene expression.
Aim 2: Identify the selective cellular vulnerabilities that define cerebral small vessel disease- and Alzheimer disease-related WMD
Investigator: Jonathan Kipnis
Project Title: Continuous perivascular space allows brain macromolecules efflux to the dura mater
Date: April 15, 2023
Request ID: T2305
Aim 1: Define arteriovenous overlaps in the human leptomeninges.
Aim 2: Determine the ultrastructure of arteriovenous overlaps of non-dementia and Alzheimer’s disease patients.