Search Existing Tissue Requests

The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.

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Investigator: Hongyu An

Project Title: Neuroinflammation in Cerebral Small Vessel Disease using PET/MR Imaging

Date: March 14, 2023

Request ID: T2302

Aim 1: Determine if S1PR1 expression increases and colocalizes with microglia and astrocytes in post-mortem brain specimens from deceased patients with underlying CSVD.

Aim 2: Determine if neuroinflammation measured by 11C-CS1P1 uptake is independently associated with CSVD structural endpoints using in vivo PET/MR imaging.

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Investigator: Zachary McEachin

Project Title: Assessment of cryptic exons in TDP-43 proteinopathies

Date: February 14, 2023

Request ID: T2301

Aim 1: Determine the abundance of cryptic exons across FTLD-TDP subtypes

Aim 2: Determine the proteomic signatures associated with distinct TDP-43 subtypes

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Investigator: Cruchaga

Project Title: Tissue request T1225. Second Amendment Brain RNA levels, protein levels and Alzheimer’s Disease: deep molecular profiling

Date: February 12, 2023

Request ID: T1225-B

Aim 1: Identification and Characterization of Cell-Specific Transposable Elements Implicated on Alzheimer Disease and Healthy Aging

Aim 2: To generate neuron and microglia specific ATAC-seq, CAGE-seq, DNA methylation and long-reads RNA-seq

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Investigator: A/Prof Matthew Pase

Project Title: Plasma inflammatory biomarkers for the diagnosis of dementia subtypes

Date: February 8, 2023

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Aim 1: To determine the diagnostic accuracy of selected blood neuroinflammatory biomarkers

Aim 2: To determine if blood biomarkers of neuroinflammation correlate with established neurodegenerative disease biomarkers

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Investigator: Chengjie Xiong

Project Title: R01 Cross Sectional and Longitudinal Racial Disparity in Molecular Biomarkers of AD

Date: November 25, 2022

Request ID: T2219

Aim 1: To implement a central and standardized processing protocol for retrospectively and prospectively collected plasma samples and a harmonized assessment protocol of SDOH across the sites, and to determine cross-sectional and longitudinal racial differences in plasma amyloid and pTau biomarkers.

Aim 2: To determine racial differences in the correlations of plasma biomarkers with CSF and imaging biomarkers, as well as concurrent and future clinical and cognitive outcomes.

Aim 3: To assess racial differences in plasma NfL and GFAP, and whether the differences are modified by risk factors for vascular disease: MRI white matter hyperintensities (WMH), BMI, and HbA1c.

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Investigator: Marta Barrachina

Project Title: Identification and characterization of mitochondrial methylcytosines as novel blood-based biomarkers for predicting Alzheimer’s disease dementia progression at mild cognitive impairment stage

Date: November 17, 2022

Request ID: T2218

Aim 1: To develop a model to classify patients diagnosed with Mild Cognitive Impairment susceptible to progressing to Alzheimer’s disease dementia.

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Investigator: Bruno A. Benitez and Collaborators: Oscar Harari and Mark Sands

Project Title: Multi-omic approach to Autosomal dominant adult-onset neuronal ceroid lipofuscinosis

Date: November 15, 2022

Request ID: T1108-B

Aim 1: Aim 1: To establish a cellular and molecular map of DNAJC5-associated neurodegenerative pathways.

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Investigator: Carlos Cruchaga

Project Title: Functional characterization of novel Alzheimer disease related genes using induced pluripotent stem cell models

Date: October 14, 2022

Request ID: T2217

Aim 1: To determine whether novel variants on chromosomes 3 and 19 modify sTREM2 levels and impact TREM2 and microglia function in cellular models

Aim 2: To study the effect of Chr 3 gene region OSTN/GMNC/IL1RAP on tau and calcineurin metabolism in iPSC-derived neurons

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Investigator: Suzanne Schindler

Project Title: Evaluation of plasma tau in the Knight ADRC cohort

Date: August 21, 2022

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Aim 1: Measurement of plasma p-tau in most Knight ADRC samples

Aim 2: Extensive characterization of plasma tau species in a subset of informative samples

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Investigator: Diana Farmer/Aijun Wang (mPI)

Project Title: Engineered Targeted Extracellular Vesicles for Neurovascular Unit Restoration in Brain Organoid Model of Alzheimer’s Disease

Date: June 19, 2022

Request ID: T2215

Aim 1: Generate Ex Vivo Model of Alzheimer’s disease Using Human Brain Organoids Derived from Induced Pluripotent Stem Cells

Aim 2: Examine preferential neuron uptake, reduced blood-brain barrier permeability, increased angiogenesis, and glial cell modulation by astrocyte-derived extracellular vesicles in human brain organoid model

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