The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Janardan P. Pandey
Project Title: Immunoglobulin GM Allotypes in Alzheimer’s Disease
Date: June 27, 2022 at 11:20 am
Request ID: D2209
Aim 1: Determine if GM allotypes are risk factors for Alzheimer’s disease in African Americans
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Investigator: John Morris
Project Title: Predictors and Outcomes of Clinical Dementia Rating Reversion.
Date: April 27, 2022 at 9:15 am
Request ID: D2208
Aim 1: To understand the clinical significance of individuals who revert between cognitive normality and meeting the clinical diagnostic criteria for dementia on the Clinical Dementia Rating (CDR) score, coined “reversion.”
Aim 2: To examine if reversion is related to cognition, genetics, fluid biomarkers, and neuroimaging markers.
Aim 3: To examine if instances of reversion are a predictor of future stable CDR >0 and a clinical diagnosis of Alzheimer’s Disease (AD).
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Investigator: Ron Anafi
Project Title: Circadian Organization and Disorder in Alzheimer’s Disease
Date: April 13, 2022 at 4:00 pm
Request ID: D2207
Aim 1: Examine circadian phase in post-mortem human brain tissue in AD and control using transcriptional analysis with CYCLOPS
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Investigator: Timothy J. Hohman
Project Title: Alzheimer’s Disease Sequencing Project Phenotype Harmonization Consortium
Date: April 4, 2022 at 3:16 pm
Request ID: D2206
Aim 1: Procure, collate, and curate endophenotype data from ADSP cohort studies
Aim 2: Harmonize data from ADSP cohort studies leveraging advanced statistical approaches
Aim 3: Disseminate harmonization protocols and harmonized phenotypes to the research community
Aim 4: Educate the research community on available harmonized resources and best practices
Investigator: Brian Gordon
Project Title: Comparing biomarkers between Down Syndrome, Autosomal Dominant, and Late onset Alzheimer Disease
Date: March 25, 2022 at 5:36 pm
Request ID: D2205
Aim 1: How do measures of tau pathology measured using PET compare among DS, ADAD, and LOAD?
Aim 2: Does the spread of tau pathology over time differ between cohorts?
Aim 3: How do the degree and spatial patterns of neurodegeneration compare between DS, ADAD, and LOAD?
Aim 4: How do biofluid profiles compare between DS, ADAD, and LOAD? We will expand upon our prior publication
Investigator: Karin Meeker
Project Title: Alzheimer disease heterogeneity profiles in ethno-racial minorities
Date: March 25, 2022 at 2:36 pm
Request ID: D2204
Aim 1: Determine AD brain volume heterogeneity profiles of neuroimaging markers (i.e., magnetic resonance imaging [MRI], resting-state functional connectivity [RS-FC]), cognition, and AD biomarkers (i.e., plasma amyloid and tau).
Aim 2: Assess group differences in heterogeneity profiles between Blacks and Non-Hispanic Whites.
Aim 3: Determine whether social determinants of health (SDOH; e.g., ADI) mediate group differences in heterogeneity profiles.
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Investigator: Jennifer Shearon
Project Title: Exercise as a mediator of the effects of personality on vascular and brain health
Date: March 11, 2022 at 2:44 pm
Request ID: D2203
Aim 1: The primary goal of this project is to examine whether long-term exercise engagement and exercise variability mediate the effects of personality on vascular health and brain structure.
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Investigator: Brice McConnell, MD, PhD
Project Title: An Assessment of Novel Sleep-Related Neurophysiological Events in the Context of Cognitive Impairment and Alzheimer’s Disease
Date: February 16, 2022 at 9:55 pm
Request ID: D2202
Aim 1: Aim 1: Elucidate the relationship(s) between loss of theta burst power and longitudinal cognitive performance
Aim 2: Exploratory Aim 1: Examine the relationship between slow wave sleep composition and Alzheimer’s disease pathology
Aim 3: Exploratory Aim 2: Examine the relationship between slow wave sleep composition and longitudinal cognitive performance
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Investigator: Mark McAvoy
Project Title: The relationship of BOLD mean and standard deviation to iron deposition in healthy aging and dementia
Date: January 24, 2022 at 9:35 am
Request ID: D2125
Aim 1: Explore the affect iron deposition has on the BOLD mean and standard deviation.
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Investigator: Sylvia Villeneuve
Project Title: In unimpaired older adults, tau PET predicts near-term development of Mild Cognitive Impairment
Date: January 24, 2022 at 9:29 am
Request ID: D2126
Aim 1: We aim to elucidate whether elevated tau- positron emission tomography (PET) signal, in the presence of elevated Aβ, prospectively predict short-term conversion from cognitively unimpaired to mild cognitive impairment (MCI).
Aim 2: We are interested whether the presence of neurodegeneration (smaller hippocampal volume or thinner cortex in temporal regions) added predictive values to the amyloid and tau PET biomarkers.
Aim 3: Given that we have found results providing evidence to support our hypotheses regarding aim 1 and 2, we would like to try to replicate our findings in a separate cohort.
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