The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Arthi Venkatesan
Project Title: Replication of an Inverse Association between the Hippocampus and Caudate
Date: December 21, 2021 at 5:17 pm
Request ID: D2112
Aim 1: Determine whether we can replicate the inverse association between hippocampal and caudate volume in a larger sample of clinically normal older adults.
Aim 2: Determine whether the inverse association extends to other brain regions in the networks supporting the two navigation/memory systems.
Aim 3: Examine the inverse association between hippocampal and caudate volumes across AD stages, particularly the preclinical AD stages.
Aim 4: Assess whether there are differential associations of cognitive tasks with hippocampal and caudate volume.
Investigator: Shea Andrews
Project Title: Association of mitochondrial DNA copy number with AD neuropathological change
Date: December 21, 2021 at 5:17 pm
Request ID: D2018
Aim 1: Evaluate association of mitochondrial DNA copy number with neuropathological diagnosis of AD
Aim 2: Evaluate association of mitochondrial DNA copy number with AD neuropathology
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Investigator: Jason Hassenstab
Project Title: Does sundowning occur in preclinical and early stage Alzheimer disease?
Date: December 21, 2021 at 5:17 pm
Request ID: D2017
Aim 1: Assessing whether increasing AD pathology is associated with mild sundowning behaviors, manifesting in short term decline in cognition even in the asymptomatic preclinical and early symptomatic stages of Alzheimer disease.
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Investigator: Nure Alom Nobel
Project Title: Alzheimer’s Disease Detection Using Deep Learning.
Date: December 21, 2021 at 5:17 pm
Request ID: D2016
Aim 1: How Alzheimer’s Disease affects the human brain and what changes are made in the brain.
Aim 2: We can know whether a patient has AD or not.
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Investigator: Jorge J Llibre-Guerra
Project Title: Proposal for comparison between Dominantly Inherited Alzheimer Disease and sporadic early-onset Alzheimer’s disease.
Date: December 21, 2021 at 5:17 pm
Request ID: D2015
Aim 1: To compare clinical presentation, neuropsychological performance and cognitive decline rate between DIAD and sporadic EOAD.
Aim 2: To examine in vivo the regional distribution of tau, amyloid-β, brain glucose metabolism, and structural atrophy, as well as their relationships, in DIAD and sporadic EOAD.
Aim 3: To compare CSF biomarkers levels and rate of change in DIAD and sporadic EOAD.
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Investigator: Aristeidis Sotiras
Project Title: Machine learning to quantify spatial patterns of neuroimaging biomarkers
Date: December 21, 2021 at 5:17 pm
Request ID: D1916
Aim 1: Quantify patterns of structural covariance at the individual level and investigate their relationship with neuropsych performance measures, clinical, and laboratory values
Aim 2: Quantify patterns of coordinated amyloid deposition at the individual level and investigate their relationship with neuropsych performance measures, clinical, and laboratory values
Aim 3: Quantify patterns of coordinated tau deposition at the individual level and investigate their relationship with neuropsych performance measures, clinical, and laboratory values
Aim 4: Quantify patterns of coordinated dti metric covariation at the individual level and investigate their relationship with neuropsych performance measures, clinical, and laboratory values
Investigator: John Morris
Project Title: Hierarchical Clustering of AD Biomarkers
Date: December 21, 2021 at 5:17 pm
Request ID: D1915
Aim 1: Examine clustering of ADRC biomarkers
Aim 2: Compare clustering as a function of disease stage
Aim 3: Comparing clustering to that seen in ADAD
Aim 4: Generate interactive GUI to plot biomarkers against one another
Investigator: Sheng Luo, PhD
Project Title: Integrative modeling and dynamic prediction of Alzheimer�s disease
Date: December 21, 2021 at 5:17 pm
Request ID: D1914
Aim 1: To develop a novel integrative modeling framework for clinical studies of AD that collect longitudinal clinical data.
Aim 2: To generalize the integrative modeling framework for the joint analysis of longitudinal clinical data and high-dimensional MRI data.
Aim 3: To advance the integrative modeling framework to incorporate relevant genetic markers from genome-wide association studies.
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Investigator: Lucey
Project Title: Relationship of actigraphic sleep and circadian rhythms to longitudinal change in cognition and AD biomarkers
Date: December 21, 2021 at 5:17 pm
Request ID: D1913
Aim 1: To determine the feasibility of a grant application examining the relationship between actigraphic sleep and circadian parameters to longitudinal change in cognition and AD biomarkers from multiple AD cohorts
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Investigator: Jason Hassenstab
Project Title: Comparison of the Montreal Cognitive Assessment (MoCA) with standard cognitive measures and AD biomarkers.
Date: December 21, 2021 at 5:17 pm
Request ID: D1912
Aim 1: To determine if the MoCA subdomain and total scores are comparable to standard neuropsychological measures.
Aim 2: Compared to standard cognitive measures, does the MoCA show equivalent sensitivity to clinical disase progression, as measured by AD biomarkers.
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